Somatic diversification and affinity maturation of IgM and IgG anti-DNA antibodies in murine lupus.

doi:10.1002/eji.1830231114

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Article

Somatic diversification and affinity maturation of IgM and IgG anti-DNA antibodies in murine lupus.

European journal of immunology - 1 Nov 1993

Hirose S, Wakiya M, Kawano-Nishi Y, Yi J, Sanokawa R, Taki S, Shimamura T, Kishimoto T, Tsurui H, Nishimura H

Abstract excerpt

Molecular events occurring during the process of generation of pathogenic immunoglobulin (Ig)G anti-DNA antibodies in systemic lupus erythematosus (SLE) were studied using a newly established method. We analyzed the Ig variable (V) region gene sequence and DNA-binding activity of IgM and IgG anti-DNA monoclonal antibodies (mAb) from individual SLE-prone (NZB x NZW) F1 mice. The first event appeared to be clonal...

Topics

Age Factors
Amino Acid Sequence
Animals
Antibodies, Antinuclear
Antibodies, Monoclonal
Antibody Affinity
Antibody Diversity
Base Sequence
DNA
Female
Immunoglobulin G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Isotypes

Immunoglobulin M

Lupus Erythematosus, Systemic

Mice

Mice, Inbred NZB

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 8223857
DOI: 10.1002/eji.1830231114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8223857-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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