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Article

V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1990

Clarke S H, Staudt L M, Kavaler J, Schwartz D, Gerhard W U, Weigert M G

Abstract excerpt

Most (80 to 90%) primary antibodies specific for the Sb site of influenza virus (A/PR/8/34) hemagglutinin share an Id (designated C4). Secondary antihemagglutinin(Sb) antibodies also exhibit the C4 Id although less frequently (10 to 15%). We have analyzed the V region nucleotide sequences of primary and secondary antibodies with the C4 Id. Primary C4 antibodies are encoded by the same Vk gene, belonging to the...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibodies, Viral
Base Sequence
Blotting, Southern
Genes, Immunoglobulin
Hemagglutinins, Viral
Immunoglobulin Heavy Chains
Immunoglobulin Idiotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Immunoglobulin kappa-Chains

Immunologic Memory

Influenza A virus

Mice

Mice, Inbred BALB C

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 2108213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2108213-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin.PMID 2108213Read ↗

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