Article
Use of a single VH family and long CDR3s in the variable region of cattle Ig heavy chains.
International immunology - 1 Jan 1997
Berens S J, Wylie D E, Lopez O J
Abstract excerpt
We have analyzed transcripts encoding the variable regions of Ig heavy chains from adult and fetal bovine splenocytes and bovine x mouse heterohybridomas. The 13 adult, seven fetal and two heterohybridomas transcripts as well as the six genes that were sequenced had > 83% identity to each other in the VH-encoded regions (FRs 1-3 and CDRs 1 and 2). By this criterion, all the bovine sequences were assigned to one...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Immunoglobulin Heavy Chains
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Mice
- Molecular Sequence Data
- Multigene Family