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Article

Human splenic IgM immunoglobulin transcripts are mutated at high frequency.

Molecular immunology - 1 Apr 1994

Insel R A, Varade W S, Marin E

Abstract excerpt

Human spleen immunoglobulin gene rearrangements that used the VH6 gene and were expressed with IgM were characterized for their frequency of somatic hypermutation from PCR amplified spleen cDNA. A high frequency of rearrangements that were somatically mutated was demonstrated by restriction endonuclease analysis and sequencing of cloned rearrangements. The 24 rearrangements cloned from three different spleens had...

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Identifiers

PMID: 8152441
DOI: 10.1016/0161-5890(94)90116-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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