Human splenic IgM immunoglobulin transcripts are mutated at high frequency.

doi:10.1016/0161-5890(94)90116-3

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Article

Human splenic IgM immunoglobulin transcripts are mutated at high frequency.

Molecular immunology - 1 Apr 1994

Insel R A, Varade W S, Marin E

Abstract excerpt

Human spleen immunoglobulin gene rearrangements that used the VH6 gene and were expressed with IgM were characterized for their frequency of somatic hypermutation from PCR amplified spleen cDNA. A high frequency of rearrangements that were somatically mutated was demonstrated by restriction endon...

Topics

Amino Acid Sequence
Base Sequence
Gene Rearrangement
Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains
Immunoglobulin M
Immunoglobulin Variable Region
Molecular Sequence Data
Mutation
RNA, Messenger
Spleen

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