Article
Variable region genes of anti-HIV human monoclonal antibodies: non-restricted use of the V gene repertoire and extensive somatic mutation.
Molecular immunology - 1 Nov 1993
Moran M J, Andris J S, Matsumato Y, Capra J D, Hersh E M
Abstract excerpt
The extent of the expressed human V gene repertoire for the most part has been derived from fetal cDNA libraries, autoantibodies, and myeloma proteins. In order to continue to explore the utilization of the VH and VL gene repertoire in response to exogenous viral antigens, the heavy and light cha...
Topics
- Amino Acid Sequence
- Antibody Diversity
- Base Sequence
- DNA, Complementary
- Genes, Immunoglobulin
- HIV Antibodies
- Humans
- Hybridomas
- Immunoglobulin Heavy Chains
- Immunoglobulin Joining Region
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation