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Article

Variable region genes of anti-HIV human monoclonal antibodies: non-restricted use of the V gene repertoire and extensive somatic mutation.

Molecular immunology - 1 Nov 1993

Moran M J, Andris J S, Matsumato Y, Capra J D, Hersh E M

Abstract excerpt

The extent of the expressed human V gene repertoire for the most part has been derived from fetal cDNA libraries, autoantibodies, and myeloma proteins. In order to continue to explore the utilization of the VH and VL gene repertoire in response to exogenous viral antigens, the heavy and light chain cDNAs from four human anti-HIV monoclonal antibodies were PCR amplified from human-mouse heterohybridomas, cloned,...

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Identifiers

PMID: 8232339
DOI: 10.1016/0161-5890(93)90462-k

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