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Article

Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas.

European journal of immunology - 1 Jul 1992

Winkler T H, Fehr H, Kalden J R

Abstract excerpt

The molecular mechanisms leading to anti-double-stranded (ds) DNA antibody production in systemic lupus erythematosus (SLE) are poorly understood. We describe here the immunoglobulin variable region genes of six human hybridomas secreting IgG anti-dsDNA antibodies derived from three SLE patients. The monoclonal IgG anti-dsDNA antibodies have been shown to be of high affinity and no multireactivity was observed...

Topics

Amino Acid Sequence
Antibodies, Antinuclear
Base Sequence
Cloning, Molecular
DNA
Genes, Immunoglobulin
Humans
Hybridomas
Immunoglobulin G
Immunoglobulin Heavy Chains
Immunoglobulin Light Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Lupus Erythematosus, Systemic

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 1623920
DOI: 10.1002/eji.1830220709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1623920-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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