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Article

Characterization of the Interaction of FKBP12 with the Transforming Growth Factor-β Type I Receptor in Vivo

1 Sept 1996

Abstract excerpt

The type I transforming growth factor-beta receptor (TbetaR-I) is the efferent component of the receptor complex, which presumably phosphorylates intracellular targets. FKBP12, a binding protein for FK506 and rapamycin, is shown to associate with the cytoplasmic region of TbetaR-I in vitro. In this report, we investigated the interaction of FKBP12 with TbetaR-I in vivo. FKBP12 interacts with TbetaR-I in mammalian...

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PMID: 8702959
DOI: 10.1074/jbc.271.36.21687

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