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Article

FK506-binding protein 12 modulates μ-opioid receptor phosphorylation and protein kinase C(ε)-dependent signaling by its direct interaction with the receptor.

Molecular pharmacology - 1 Jan 2014

Qiu Yu, Zhao Wei, Wang Yan, Xu Jian-Rong, Huie Eddie, Jiang Shan, Yan Ying-Hui, Loh Horace H, Chen Hong-Zhuan, Law Ping-Yee

Abstract excerpt

Protein kinase C (PKC) activation plays an important role in morphine-induced μ-opioid receptor (OPRM1) desensitization and tolerance development. It was recently shown that receptor phosphorylation by G protein-coupled receptor kinase regulates agonist-dependent selective signaling and that inefficient phosphorylation of OPRM1 leads to PKCε activation and subsequent responses. Here, we demonstrate that such...

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Source

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Identifiers

PMID: 24113748
DOI: 10.1124/mol.113.087825
PMCID: PMC3868904

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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