Article
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
Science (New York, N.Y.) - 12 Jul 1996
Choi J, Chen J, Schreiber S L, Clardy J
Abstract excerpt
Rapamycin, a potent immunosuppressive agent, binds two proteins: the FK506-binding protein (FKBP12) and the FKBP-rapamycin-associated protein (FRAP). A crystal structure of the ternary complex of human FKBP12, rapamycin, and the FKBP12-rapamycin-binding (FRB) domain of human FRAP at a resolution...
Topics
- Binding Sites
- Carrier Proteins
- Crystallography, X-Ray
- DNA-Binding Proteins
- Heat-Shock Proteins
- Humans
- Immunophilins
- Models, Molecular
- Mutation
- Phosphotransferases (Alcohol Group Acceptor)
- Polyenes
- Protein Conformation