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Article

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.

Science (New York, N.Y.) - 12 Jul 1996

Choi J, Chen J, Schreiber S L, Clardy J

Abstract excerpt

Rapamycin, a potent immunosuppressive agent, binds two proteins: the FK506-binding protein (FKBP12) and the FKBP-rapamycin-associated protein (FRAP). A crystal structure of the ternary complex of human FKBP12, rapamycin, and the FKBP12-rapamycin-binding (FRB) domain of human FRAP at a resolution of 2.7 angstroms revealed the two proteins bound together as a result of the ability of rapamycin to occupy two...

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Identifiers

PMID: 8662507
DOI: 10.1126/science.273.5272.239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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