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FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells

30 Jan 2023

Abstract excerpt

BACKGROUND: The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 with drugs such as the FKBP-ligand FK506 enhances BMP activity in various cell types. In multiple myeloma cells, activation of SMAD1/5/8 leads to apoptosis. We hypothesized that removing FKBP12...

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PMID: 36717825
DOI: 10.1186/s12964-022-01033-9

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