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Article

Regulation of calcineurin phosphatase activity and interaction with the FK-506.FK-506 binding protein complex.

The Journal of biological chemistry - 29 Jul 1994

Parsons J N, Wiederrecht G J, Salowe S, Burbaum J J, Rokosz L L, Kincaid R L, O'Keefe S J

Abstract excerpt

The immunosuppressant FK-506 (tacrolimus) forms a complex with a ubiquitous intracellular receptor, FK-506 binding protein (FKBP12), and this complex inhibits the heterodimeric Ca2+/calmodulin-dependent phosphatase, calcineurin, an essential component of the T-cell receptor signal transduction pathway. Using a series of truncated calcineurin catalytic subunits, we show here that a region within the catalytic...

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PMID: 7518461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Regulation of calcineurin phosphatase activity and interaction with the FK-506.FK-506 binding protein complex.PMID 7518461Read ↗

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