Article
Regulation of calcineurin phosphatase activity and interaction with the FK-506.FK-506 binding protein complex.
The Journal of biological chemistry - 29 Jul 1994
Parsons J N, Wiederrecht G J, Salowe S, Burbaum J J, Rokosz L L, Kincaid R L, O'Keefe S J
Abstract excerpt
The immunosuppressant FK-506 (tacrolimus) forms a complex with a ubiquitous intracellular receptor, FK-506 binding protein (FKBP12), and this complex inhibits the heterodimeric Ca2+/calmodulin-dependent phosphatase, calcineurin, an essential component of the T-cell receptor signal transduction pa...
Topics
- Amino Acid Sequence
- Calcineurin
- Calmodulin-Binding Proteins
- Carrier Proteins
- Gene Expression Regulation, Enzymologic
- Heat-Shock Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Phosphoprotein Phosphatases
- Phosphoric Monoester Hydrolases
- Sequence Deletion
- Structure-Activity Relationship
- T-Lymphocytes
- Tacrolimus
- Tacrolimus Binding Proteins