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Article

The effect of FK506 on transforming growth factor beta signaling and apoptosis in chronic lymphocytic leukemia B cells.

Haematologica - 1 Jul 2008

Romano Simona, Mallardo Maria, Chiurazzi Federico, Bisogni Rita, D'Angelillo Anna, Liuzzi Raffaele, Compare Giovanna, Romano Maria Fiammetta

Abstract excerpt

BACKGROUND: Loss of response to transforming growth factor-beta (TGF-beta ) is thought to contribute to the progression of chronic lymphocytic leukemia. Recent findings of over-activation of the TGF-beta signal in FKBP12-knockout mouse prompted us to investigate whether FK506, the canonical ligand of FKBP, can activate the TGF-beta signal in chronic lymphocytic leukemia. DESIGN AND METHODS: We studied 62 chronic...

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Identifiers

PMID: 18492692
DOI: 10.3324/haematol.12402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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