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FAP48, a New Protein That Forms Specific Complexes with Both Immunophilins FKBP59 and FKBP12

1 Dec 1996

Abstract excerpt

We have identified a human gene encoding a 48-kDa protein that specifically interacts with the peptidyl prolyl isomerase FK506-binding protein 59 (FKBP59) and also with the well known FKBP12. FKBP59 and FKBP12 belong to the large family of immunophilins that bind the macrolide immunosuppressant drugs FK506 and rapamycin. The yeast two-hybrid system was used to isolate target proteins that interact with the...

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PMID: 8955134
DOI: 10.1074/jbc.271.51.32923

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