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Article

Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization.

Neuroscience letters - 30 Apr 2014

Yan Ying-Hui, Wang Yan, Zhao Lan-Xue, Jiang Shan, Loh Horace H, Law Ping-Yee, Chen Hong-Zhuan, Qiu Yu

Abstract excerpt

Agonist-activated μ-opioid receptor (OPRM1) undergoes robust receptor phosphorylation by G protein-coupled receptor kinases and subsequent β-arrestin recruitment, triggering receptor internalization and desensitization. Morphine, a widely prescribed opioid, induces receptor phosphorylation inefficiently. Previously we reported that FK506 binding protein 12 (FKBP12) specifically interacts with OPRM1 and such...

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Identifiers

PMID: 24607931
DOI: 10.1016/j.neulet.2014.02.059
PMCID: PMC4010564

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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