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Article

FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Oct 1997

Alarcón C M, Heitman J

Abstract excerpt

The peptidyl-prolyl isomerase FKBP12 was originally identified as the intracellular receptor for the immunosuppressive drugs FK506 (tacrolimus) and rapamycin (sirolimus). Although peptidyl-prolyl isomerases have been implicated in catalyzing protein folding, the cellular functions of FKBP12 in Saccharomyces cerevisiae and other organisms are largely unknown. Using the yeast two-hybrid system, we identified...

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Identifiers

PMID: 9315655
DOI: 10.1128/MCB.17.10.5968
PMCID: PMC232445

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