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Article

[Intracellular calcium-releasing channels as cellular targets for immunophilins: a molecular, functional and structural analysis].

Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie - 1 Jan 2004

Bultynck G, Van Acker K, Missiaen L, Callewaert G, Parys J B, De Smedt H

Abstract excerpt

In this study, the FKBP12-binding properties of IP3Rs and RyRs were compared. Although the primary sequence of IP3Rs en RyRs contained a putative FKBP12-binding site, the functional, molecular and structural properties of these sites appeared to be completely different. For RyRs, FKBPs appear to function as associated proteins that are important for the functional regulation of the channel, thereby stabilizing...

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Source

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PMID: 15553100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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