Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conclusion of LOD-score analysis for family data generated under two-locus models.

American journal of human genetics - 1 Jun 1996

Dizier M H, Babron M C, Clerget-Darpoux F

Abstract excerpt

The power to detect linkage by the LOD-score method is investigated here for diseases that depend on the effects of two genes. The classical strategy is, first, to detect a major-gene (MG) effect by segregation analysis and, second, to seek for linkage with genetic markers by the LOD-score method...

Topics

Alleles
Family
Female
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Humans
Lod Score
Male
Models, Genetic
Models, Statistical
Pedigree
Software

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 8651311
PMCID: PMC1915060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8651311-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conclusion of LOD-score analysis for family data generated under two-locus models.PMID 8651311Read ↗

Conclusions of segregation analysis for family data generated under two-locus models.Semantic proximity Read ↗

Model misspecification and multipoint linkage analysis.Semantic proximity Read ↗

Two-locus disease models with two marker loci: the power of affected-sib-pair tests.Semantic proximity Read ↗

Linkage analysis versus association analysis: distinguishing between two models that explain disease-marker associations.Semantic proximity Read ↗

Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases.Semantic proximity Read ↗

Effect of heterogeneity and assumed mode of inheritance on lod scores.Semantic proximity Read ↗

Correcting for ascertainment bias of relative-risk estimates obtained using affected-sib-pair linkage data.Semantic proximity Read ↗

Detection of linkage under heterogeneity: comparison of the two-locus vs. admixture models.Semantic proximity Read ↗

Distribution of lod scores under uncertain mode of inheritance.Semantic proximity Read ↗

The affected-pedigree-member method: power to detect linkage.Semantic proximity Read ↗

Analysis of genetic linkage data for Mendelian traits.Semantic proximity Read ↗

Two-locus heterogeneity cannot be distinguished from two-locus epistasis on the basis of affected-sib-pair data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.