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Article

Conclusions of segregation analysis for family data generated under two-locus models.

American journal of human genetics - 1 Dec 1993

Dizier M H, Bonaïti-Pellié C, Clerget-Darpoux F

Abstract excerpt

Susceptibility to a disease may involve the interactive effect of two genes. What conclusions will be drawn by segregation analysis in such a case? To answer this question, we considered a set of two-locus models and the corresponding exact distribution for 300 families. We investigated the conclusions and parameter estimations obtained for this sample, by comparing the likelihood expectations of the unified...

Topics

Alleles
Computer Simulation
Gene Expression Regulation
Gene Frequency
Genetic Predisposition to Disease
Humans
Likelihood Functions
Models, Genetic
Software

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8250049
PMCID: PMC1682497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8250049-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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