Two-locus heterogeneity cannot be distinguished from two-locus epistasis on the basis of affected-sib-pair data.

Abstract excerpt

The observation of multiple linkage signals in the course of conducting genome screens for complex disorders raises the question of whether distinct genes represent independent causes of disease (heterogeneity) or whether they interact to produce the phenotype of interest (epistasis); and there has been a corresponding interest in statistical methods for detecting and/or exploiting the distinction between these...

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