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Article

Model misspecification and multipoint linkage analysis.

Human heredity - 1 Jan 1992

Risch N, Giuffra L

Abstract excerpt

Pairwise linkage analysis is robust to genetic model misspecification provided dominance is correctly specified, the primary effect being inflation of the recombination fraction. By contrast, we show that multipoint analysis under misspecified models is not robust when a putative disease locus is placed between close flanking markers, with potentially spuriously negative multipoint lod scores being produced. The...

Topics

Animals
Data Interpretation, Statistical
Genes, Dominant
Genes, Recessive
Genetic Linkage
Genetic Variation
Humans
Lod Score
Models, Genetic
Pedigree
Probability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1555848
DOI: 10.1159/000154047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1555848-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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