Detection of linkage under heterogeneity: comparison of the two-locus vs. admixture models.

doi:10.1002/gepi.1370090107

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Article

Detection of linkage under heterogeneity: comparison of the two-locus vs. admixture models.

Genetic epidemiology - 1 Jan 1992

Goldin L R

Abstract excerpt

Linkage analysis under the two-locus model and the admixture model was compared on pedigree data for a common disease stimulated under a model of genetic heterogeneity. The ascertainment of families was designed so that the samples had a large proportion of families segregating for both disease l...

Topics

Chromosome Mapping
Computer Simulation
Female
Genetic Linkage
Humans
Male
Models, Genetic
Pedigree
Phenotype
Recombination, Genetic

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