The affected-pedigree-member method: power to detect linkage.

doi:10.1159/000154250

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Article

The affected-pedigree-member method: power to detect linkage.

Human heredity - 1 Jan 2000

Weeks D E, Harby L D

Abstract excerpt

The affected-pedigree-member (APM) method of linkage analysis is a nonparametric statistic for testing for nonindependent segregation of a marker to affected members of a pedigree. We present here results of a simulation study evaluating the power of the APM method to detect linkage. We have syst...

Topics

Alleles
Computer Simulation
Female
Genetic Heterogeneity
Genetic Linkage
Humans
Male
Pedigree
Phenotype
Polymorphism, Genetic

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