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Article

Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases.

American journal of human genetics - 1 Sept 1999

Abreu P C, Greenberg D A, Hodge S E

Abstract excerpt

Several methods have been proposed for linkage analysis of complex traits with unknown mode of inheritance. These methods include the LOD score maximized over disease models (MMLS) and the "nonparametric" linkage (NPL) statistic. In previous work, we evaluated the increase of type I error when maximizing over two or more genetic models, and we compared the power of MMLS to detect linkage, in a number of complex...

Topics

Gene Frequency
Genes, Dominant
Genes, Recessive
Genetic Diseases, Inborn
Genetic Linkage
Genotype
Humans
Likelihood Functions
Lod Score
Models, Genetic
Penetrance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sensitivity and Specificity

Statistics, Nonparametric

Source

Open in PubMed Open full text

Identifiers

PMID: 10441591
DOI: 10.1086/302536
PMCID: PMC1377991

Genes

NPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10441591-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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