Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two-locus disease models with two marker loci: the power of affected-sib-pair tests.

American journal of human genetics - 1 Nov 1994

Knapp M, Seuchter S A, Baur M P

Abstract excerpt

Recently, Schork et al. found that two-trait-locus, two-marker-locus (parametric) linkage analysis can provide substantially more linkage information than can standard one-trait-locus, one-marker-locus methods. However, because of the increased burden of computation, Schork et al. do not expect that their approach will be applied in an initial genome scan. Further, the specification of a suitable two-locus...

Topics

Alleles
Chromosome Mapping
Genetic Diseases, Inborn
Genetic Linkage
Humans
Models, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7977340
PMCID: PMC1918345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7977340-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two-locus disease models with two marker loci: the power of affected-sib-pair tests.PMID 7977340Read ↗

The power of two-locus affected sib-pair linkage analysis to detect interacting disease loci.Semantic proximity Read ↗

Two-stage two-locus models in genome-wide association.Semantic proximity Read ↗

Robust multipoint identical-by-descent mapping for affected relative pairs.Semantic proximity Read ↗

Detecting gene-gene interactions using affected sib pair analysis with covariates.Semantic proximity Read ↗

Linkage strategies for genetically complex traits. II. The power of affected relative pairs.Semantic proximity Read ↗

Robust multipoint simultaneous identical-by-descent mapping for two linked loci.Semantic proximity Read ↗

Power of sib-pair and sib-trio linkage analysis with assortative mating and multiple disease loci.Semantic proximity Read ↗

Comparative power of family-based association strategies to detect disease-causing variants under two-locus models.Semantic proximity Read ↗

Statistical properties of affected sib-pair linkage tests.Semantic proximity Read ↗

Multilocus linkage tests based on affected relative pairs.Semantic proximity Read ↗

Two-locus developments of the weighted pairwise correlation method for linkage analysis.Semantic proximity Read ↗

Effect of two- and three-locus linkage disequilibrium on the power to detect marker/phenotype associations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.