Article
Analysis of genetic linkage data for Mendelian traits.
Current protocols in human genetics - 1 May 2001
Pericak-Vance M A
Abstract excerpt
This unit describes linkage analysis, an invaluable tool in mapping human disease genes. Linkage analysis is one of several methods used to map genes. Specifically, in linkage analysis cosegregation of two or more genes (traits) is examined in a family unit to determine if they segregate independently according to Mendel's laws or if they do not segregate independently because of their close physical proximity....
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