Linkage analysis versus association analysis: distinguishing between two models that explain disease-marker associations.

Article

Linkage analysis versus association analysis: distinguishing between two models that explain disease-marker associations.

American journal of human genetics - 1 Aug 1993

Hodge S E

Abstract excerpt

Human genetics researchers have been intrigued for many years by weak-to-moderate associations between markers and diseases. However, in most cases of association, the cause of this phenomenon is still not known. Recently, interest has grown in pursuing association studies for complex diseases, e...

Topics

Alleles
Chi-Square Distribution
Computer Simulation
Gene Frequency
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Humans
Linkage Disequilibrium
Models, Genetic
Models, Statistical
Pedigree
Probability
Reproducibility of Results

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