Effect of heterogeneity and assumed mode of inheritance on lod scores.

doi:10.1002/ajmg.1320420302

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Article

Effect of heterogeneity and assumed mode of inheritance on lod scores.

American journal of medical genetics - 1 Feb 1992

Durner M, Greenberg D A

Abstract excerpt

Heterogeneity is a major factor in many common, complex diseases and can confound linkage analysis. Using computer-simulated heterogeneous data we tested what effect unlinked families have on a linkage analysis when heterogeneity is not taken into account. We created 60 data sets of 40 nuclear fa...

Topics

Genetic Linkage
Humans
Lod Score
Models, Genetic
Phenotype
Recombination, Genetic

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