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Article

Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis.

The Journal of experimental medicine - 1 May 1996

Combadière B, Freedman M, Chen L, Shores E W, Love P, Lenardo M J

Abstract excerpt

Engagement of the T cell receptor (TCR) of mature T lymphocytes can lead either to activation/proliferation responses or programmed cell death. To understand the molecular regulation of these two fundamentally different outcomes of TCR signaling, we investigated the participation of various components of the TCR-CD3 complex. We found that the TCR-zeta chain, while not absolutely required, was especially effective...

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Identifiers

PMID: 8642321
DOI: 10.1084/jem.183.5.2109
PMCID: PMC2192564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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