Article
Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis.
The Journal of experimental medicine - 1 May 1996
Combadière B, Freedman M, Chen L, Shores E W, Love P, Lenardo M J
Abstract excerpt
Engagement of the T cell receptor (TCR) of mature T lymphocytes can lead either to activation/proliferation responses or programmed cell death. To understand the molecular regulation of these two fundamentally different outcomes of TCR signaling, we investigated the participation of various compo...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Base Sequence
- Cells, Cultured
- Clone Cells
- DNA
- DNA Primers
- Genetic Variation
- Lymphocyte Activation
- Membrane Proteins
- Mice
- Molecular Sequence Data
- Polymerase Chain Reaction
- Receptor-CD3 Complex, Antigen, T-Cell