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Article

Tyrosine mutation in CD3epsilon-ITAM blocked T lymphocyte apoptosis mediated by CD3epsilon.

Immunological investigations - 1 Feb 2003

Liu Yanxin, He Yiping, Zhang Jin, Jiang Liqun, Liu Shilian, Zheng Dexian

Abstract excerpt

Anti-CD3epsilon monoclonal antibody induces programmed cell death of thymocytes and accelerates activation-induced cell death (AICD) by apoptosis of matured or transformed T lymphocytes. However, the underlying molecular mechanism of this phenomenon is unclear. Therefore, we produced a chimera protein (termed CD8epsilon by fusing the extracellular and transmembrane domains of human CD8alpha to the intracellular...

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PMID: 12722942
DOI: 10.1081/imm-120019208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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