Article
Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation.
Science (New York, N.Y.) - 24 Jul 1998
Kersh E N, Shaw A S, Allen P M
Abstract excerpt
The T cell receptor (TCR) alphabeta heterodimer interacts with its ligands with high specificity, but surprisingly low affinity. The role of the zeta component of the murine TCR in contributing to the fidelity of antigen recognition was examined. With sequence-specific phosphotyrosine antibodies,...
Topics
- Animals
- Antigen-Presenting Cells
- Antigens
- CD3 Complex
- Ligands
- Lymphocyte Activation
- Membrane Proteins
- Mice
- Mice, Transgenic
- Mutation
- Peptides
- Phosphorylation
- Phosphotyrosine
- Protein-Tyrosine Kinases
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta
- Signal Transduction
- T-Lymphocytes