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Article

Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation.

Science (New York, N.Y.) - 24 Jul 1998

Kersh E N, Shaw A S, Allen P M

Abstract excerpt

The T cell receptor (TCR) alphabeta heterodimer interacts with its ligands with high specificity, but surprisingly low affinity. The role of the zeta component of the murine TCR in contributing to the fidelity of antigen recognition was examined. With sequence-specific phosphotyrosine antibodies, it was found that zeta undergoes a series of ordered phosphorylation events upon TCR engagement. Completion of...

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Identifiers

PMID: 9677202
DOI: 10.1126/science.281.5376.572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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