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Article

CD45 regulates apoptosis in peripheral T lymphocytes.

International immunology - 1 Jun 2006

Liu Zhe, Dawes Ritu, Petrova Svetla, Beverley Peter C L, Tchilian Elma Z

Abstract excerpt

Programmed cell death (apoptosis) is a key mechanism for regulating lymphocyte numbers. Murine lymph node lymphocytes cultured in vitro without added stimuli show significant levels of apoptosis over 24 h, detectable by staining with Annexin V. CD4 and CD8 T lymphocytes from transgenic (Tg) mice expressing single CD45RABC or CD45RO isoforms show increased apoptosis and the extent of apoptosis is inversely...

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Identifiers

PMID: 16621865
DOI: 10.1093/intimm/dxl032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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