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Article

Immunoreceptor tyrosine-based activation motif is required to signal pathways of receptor-mediated growth arrest and apoptosis in murine B lymphoma cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1995

Yao X R, Flaswinkel H, Reth M, Scott D W

Abstract excerpt

The B cell Ag receptor is a multimeric protein complex consisting of the ligand binding mlg and the Ig alpha/lg beta heterodimer. The cytoplasmic tails of Ig alpha and Ig beta both contain a consensus sequence termed the immunoreceptor tyrosine-based activation motif (ITAM). This motif is believed to play a critical role in the receptor-mediated signal transduction. To explore the role of ITAM in signaling for B...

Topics

Amino Acid Sequence
Animals
Apoptosis
CD8 Antigens
Cell Death
Immunoglobulins
Lymphoma, B-Cell
Mice
Molecular Sequence Data
Mutation
Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Amino Acid

Recombinant Fusion Proteins

Signal Transduction

Tumor Cells, Cultured

Source

Identifiers

PMID: 7608543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7608543-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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