Article
Structural mutations of the T cell receptor zeta chain and its role in T cell activation.
Science (New York, N.Y.) - 13 Jul 1990
Frank S J, Niklinska B B, Orloff D G, Merćep M, Ashwell J D, Klausner R D
Abstract excerpt
T cell hybridomas that express zeta zeta, but not zeta eta, dimers in their T cell receptors (TCRs) produce interleukin-2 (IL-2) and undergo an inhibition of spontaneous growth when activated by antigen, antibodies to the receptor, or antibodies to Thy-1. Hybridomas without zeta and eta were reconstituted with mutated zeta chains. Cytoplasmic truncations of up to 40% of the zeta molecule reconstituted normal...
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