Article
Structural mutations of the T cell receptor zeta chain and its role in T cell activation.
Science (New York, N.Y.) - 13 Jul 1990
Frank S J, Niklinska B B, Orloff D G, Merćep M, Ashwell J D, Klausner R D
Abstract excerpt
T cell hybridomas that express zeta zeta, but not zeta eta, dimers in their T cell receptors (TCRs) produce interleukin-2 (IL-2) and undergo an inhibition of spontaneous growth when activated by antigen, antibodies to the receptor, or antibodies to Thy-1. Hybridomas without zeta and eta were reco...
Topics
- Amino Acid Sequence
- Animals
- Cross-Linking Reagents
- Dose-Response Relationship, Immunologic
- Hybridomas
- Immunity, Cellular
- Immunoblotting
- Interleukin-2
- Ligands
- Lymphocyte Activation
- Major Histocompatibility Complex
- Mice
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Precipitin Tests
- Receptors, Antigen, T-Cell
- Signal Transduction