Article
T cell receptor-mediated signal transduction controlled by the beta chain transmembrane domain: apoptosis-deficient cells display unbalanced mitogen-activated protein kinases activities upon T cell receptor engagement.
The Journal of biological chemistry - 8 Feb 2002
Teixeiro Emma, Fuentes Patricia, Galocha Begona, Alarcon Balbino, Bragado Rafael
Abstract excerpt
The bases that support the versatility of the T cell receptor (TCR) to generate distinct T cell responses remain unclear. We have previously shown that mutant cells in the transmembrane domain of TCRbeta chain are impaired in TCR-induced apoptosis but are not affected in other functions. Here we describe the biochemical mechanisms by which this mutant receptor supports some T cell responses but fails to induce...
Topics
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Apoptosis
- Humans
- Jurkat Cells
- Lectins, C-Type
- Mitogen-Activated Protein Kinases
- Mutation
- Phosphorylation
- Precipitin Tests
- Protein Kinase C
- Protein Transport