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Article

T cell division and death are segregated by mutation of TCRbeta chain constant domains.

Immunity - 1 Oct 2004

Teixeiro Emma, Daniels Mark A, Hausmann Barbara, Schrum Adam G, Naeher Dieter, Luescher Immanuel, Thome Margot, Bragado Rafael, Palmer Ed

Abstract excerpt

We have studied the role of the T cell receptor (TCR) beta chain transmembrane and cytoplasmic domains (betaTM/Cyto) in T cell signaling. Upon antigen stimulation, T lymphocytes expressing a TCR with mutant and betaTM and Cyto domains accumulate in large numbers and are specifically defective in undergoing activation-induced cell death (AICD). The mutant TCR poorly recruits the protein adaptor Carma-1 and is...

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Source

Identifiers

PMID: 15485629
DOI: 10.1016/j.immuni.2004.08.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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