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Article

Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire.

The Journal of experimental medicine - 3 Mar 1997

Shores E W, Tran T, Grinberg A, Sommers C L, Shen H, Love P E

Abstract excerpt

Immature thymocytes undergo a selection process within the thymus based on their T cell antigen receptor (TCR) specificity that results either in their maturation into functionally competent, self-MHC-restricted T cells (positive selection) or their deletion (negative selection). The outcome of thymocyte selection is thought to be controlled by signals transduced by the TCR that vary in relation to the avidity of...

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Identifiers

PMID: 9120395
DOI: 10.1084/jem.185.5.893
PMCID: PMC2196173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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