Article
Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire.
The Journal of experimental medicine - 3 Mar 1997
Shores E W, Tran T, Grinberg A, Sommers C L, Shen H, Love P E
Abstract excerpt
Immature thymocytes undergo a selection process within the thymus based on their T cell antigen receptor (TCR) specificity that results either in their maturation into functionally competent, self-MHC-restricted T cells (positive selection) or their deletion (negative selection). The outcome of t...
Topics
- Animals
- Female
- Flow Cytometry
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Lymph Nodes
- Male
- Membrane Proteins
- Mice
- Mice, Transgenic
- Peptide Fragments
- Phenotype
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta