Article
TCR down-regulation controls virus-specific CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2008
Bonefeld Charlotte Menné, Haks Mariëlle, Nielsen Bodil, von Essen Marina, Boding Lasse, Hansen Ann Kathrine, Larsen Jeppe Madura, Odum Niels, Krimpenfort Paul, Kruisbeek Ada, Christensen Jan Pravsgaard, Thomsen Allan Randrup, Geisler Carsten
Abstract excerpt
The CD3gamma di-leucine-based motif plays a central role in TCR down-regulation. However, little is understood about the role of the CD3gamma di-leucine-based motif in physiological T cell responses. In this study, we show that the expansion in numbers of virus-specific CD8(+) T cells is impaired in mice with a mutated CD3gamma di-leucine-based motif. The CD3gamma mutation did not impair early TCR signaling, nor...
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