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Article

Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers

1 Jan 1995

Abstract excerpt

The CDKN2A and CDKN2B genes, encoding p16 and p15 respectively, are located on chromosome 9p21, a locus at which frequent homozygous and heterozygous deletions occur in many primary human tumors, including esophageal carcinoma. CDKN2A and CDKN2B inhibit cyclin dependent kinase 4 (CDK4) and CDK6 and control cellular proliferation by preventing entry into the S phase of the cell cycle. Their inactivation may...

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Identifiers

PMID: 8595411
DOI: 10.1093/hmg/4.10.1883

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