Article
Aberrant methylation of p16INK4a and deletion of p15INK4b are frequent events in human esophageal cancer in Linxian, China.
Carcinogenesis - 1 Jan 1999
Xing E P, Nie Y, Wang L D, Yang G Y, Yang C S
Abstract excerpt
p16INK4a and p15INK4b genes, which encode two functionally related CDK inhibitors, recently emerged as candidate tumor suppressor genes since they were both localized to 9p21, which frequently undergoes hemizygous and homozygous deletion in a variety of tumor types. To determine the mode of inact...
Topics
- Carcinoma, Squamous Cell
- Carrier Proteins
- Cell Cycle
- Cell Cycle Proteins
- China
- Chromosomes, Human, Pair 9
- CpG Islands
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Methylation
- DNA, Neoplasm
- Esophageal Neoplasms
- Gene Deletion
- Genes, Tumor Suppressor
- Genes, p16
- Humans
- Loss of Heterozygosity
- Mutation