Intragenic mutations of the p16(INK4), p15(INK4B) and p18 genes in primary non-small-cell lung cancers.

doi:10.1002/(SICI)1097-0215(19960315)65:6<734::AID-IJC4>3.0.CO;2-#

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Article

Intragenic mutations of the p16(INK4), p15(INK4B) and p18 genes in primary non-small-cell lung cancers.

International journal of cancer - 15 Mar 1996

Rusin M R, Okamoto A, Chorazy M, Czyzewski K, Harasim J, Spillare E A, Hagiwara K, Hussain S P, Xiong Y, Demetrick D J, Harris C C

Abstract excerpt

The p15(INK4B), p16(INK4) and p18 genes are members of the gene family coding for inhibitors of cyclin-dependent kinases 4 and 6. p15(INK4B) and p16(INK4) are located at 9p21, a chromosomal region frequently deleted in many human neoplasms. To examine the role of these 3 genes in lung carcinogene...

Topics

Base Sequence
Carrier Proteins
Cell Cycle Proteins
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p18
DNA Mutational Analysis
Enzyme Inhibitors
Gene Deletion
Heterozygote
Humans
Lung Neoplasms
Molecular Sequence Data

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Single-Stranded Conformational

Protein Kinase Inhibitors

Source

Open in PubMed

Identifiers

PMID: 8631583
DOI: 10.1002/(SICI)1097-0215(19960315)65:6<734::AID-IJC4>3.0.CO;2-#

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8631583-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.