Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas.

doi:10.1002/gcc.2870140306

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Article

Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas.

Genes, chromosomes & cancer - 1 Nov 1995

Bartsch D, Shevlin D W, Tung W S, Kisker O, Wells S A, Goodfellow P J

Abstract excerpt

The gene encoding the cell-cycle regulatory protein p16, CDKN2, is localized on chromosome band 9p21. CDKN2 is frequently deleted or mutated in a variety of tumor cell lines, including pancreatic cancer cell lines and xenografts, as well as in some primary tumors. We examined 32 primary pancreati...

Topics

Adenocarcinoma
Carrier Proteins
Codon
Cyclin-Dependent Kinase Inhibitor p16
DNA Mutational Analysis
DNA, Neoplasm
Frameshift Mutation
Genes, Tumor Suppressor
Humans
Mutation
Pancreatic Neoplasms
Point Mutation
Sequence Deletion

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