Article
Integrative post-genome-wide association analysis of CDKN2A and TP53 SNPs and risk of esophageal adenocarcinoma.
Carcinogenesis - 1 Dec 2014
Buas Matthew F, Levine David M, Makar Karen W, Utsugi Heidi, Onstad Lynn, Li Xiaohong, Galipeau Patricia C, Shaheen Nicholas J, Hardie Laura J, Romero Yvonne, Bernstein Leslie, Gammon Marilie D, Casson Alan G, Bird Nigel C, Risch Harvey A, Ye Weimin, Liu Geoffrey, Corley Douglas A, Blount Patricia L, Fitzgerald Rebecca C, Whiteman David C, Wu Anna H, Reid Brian J, Vaughan Thomas L
Abstract excerpt
Incidence of esophageal adenocarcinoma (EA) in Western countries has increased markedly in recent decades. Although several risk factors have been identified for EA and its precursor, Barrett's esophagus (BE), including reflux, Caucasian race, male gender, obesity, and smoking, less is known about the role of inherited genetic variation. Frequent somatic mutations in the tumor suppressor genes CDKN2A and TP53...
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