Article
Low frequency of CDKN2 mutation in endometrial carcinomas.
Molecular carcinogenesis - 1 Aug 1995
Peiffer S L, Bartsch D, Whelan A J, Mutch D G, Herzog T J, Goodfellow P J
Abstract excerpt
The CDKN2 gene on chromosome 9p21 encodes the p16 inhibitor of cyclin D/cyclin-dependent kinase 4 complexes. Mutations and deletions of CDKN2 have been frequently identified in cell lines, whereas most primary tumors have demonstrated a lower frequency of alteration. To assess the role of CDKN2 i...
Topics
- Alleles
- Carcinoma
- Carrier Proteins
- Cyclin-Dependent Kinase Inhibitor p16
- DNA, Neoplasm
- Endometrial Neoplasms
- Female
- Humans
- Point Mutation
- Polymorphism, Single-Stranded Conformational