Article
p16INK4 and p15INK4B alterations in primary gynecologic malignancy.
Gynecologic oncology - 1 May 1997
Wong Y F, Chung T K, Cheung T H, Nobori T, Yim S F, Lai K W, Phil M, Yu A L, Diccianni M B, Li T Z, Chang A M
Abstract excerpt
Chromosome 9 abnormalities have been found in primary tumors and cell lines from human gynecologic malignancy. Alterations of p16INK4 and p15INK4B genes mapped on the band p21 of chromosome 9 have been detected in various human tumors, but the role of these genes as tumor suppressors in vivo appear to be dependent on tumor type. Polymerase chain reaction (PCR)-based analysis was performed to search for lesions of...
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