Article
p16INK4 and p15INK4B alterations in primary gynecologic malignancy.
Gynecologic oncology - 1 May 1997
Wong Y F, Chung T K, Cheung T H, Nobori T, Yim S F, Lai K W, Phil M, Yu A L, Diccianni M B, Li T Z, Chang A M
Abstract excerpt
Chromosome 9 abnormalities have been found in primary tumors and cell lines from human gynecologic malignancy. Alterations of p16INK4 and p15INK4B genes mapped on the band p21 of chromosome 9 have been detected in various human tumors, but the role of these genes as tumor suppressors in vivo appe...
Topics
- Carrier Proteins
- Cell Cycle Proteins
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- DNA, Neoplasm
- Female
- Genes, Tumor Suppressor
- Genital Neoplasms, Female
- Humans
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Tumor Suppressor Proteins