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Article

Genomic DNA and messenger RNA expression alterations of the CDKN2B and CDKN2 genes in esophageal squamous carcinoma cell lines.

Genes, chromosomes & cancer - 1 Aug 1995

Zhou X, Suzuki H, Shimada Y, Imamura M, Yin J, Jiang H Y, Tarmin L, Abraham J M, Meltzer S J

Abstract excerpt

The genes CDKN2B (MTS2) and CDKN2 (MTS1) encoding the proteins p15 and p16 are both located on chromosomal band 9p21, a locus at which frequent homozygous and heterozygous deletions occur in many primary human tumors, including esophageal carcinoma. CDKN2 and CDKN2B belong to a family of cyclin-dependent kinase 4 inhibitors (INK41) and control cell proliferation during the G1 phase of the cell cycle. Their...

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PMID: 7547637
DOI: 10.1002/gcc.2870130409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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