Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic loss of 9p21 and mutation of the CDKN2/p16 gene develop as early lesions during neoplastic progression in Barrett's esophagus.

Oncogene - 7 Nov 1996

Barrett M T, Sanchez C A, Galipeau P C, Neshat K, Emond M, Reid B J

Abstract excerpt

High frequency allelic loss of chromosome 9p21 has been reported in a number of human cancers, including those of the esophagus. The CDKN2 gene on chromosome 9p21 that encodes the p16 inhibitor of cyclinD/Cdk4 complexes is a target of allelic loss and inactivation in a variety of human cancers and cell lines. However, the roles of 9p21 allelic losses and CDKN2 mutations in human neoplastic progression in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Alleles
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Deletion

Share to Chromosomes, Human, Pair 9

Share to Disease Progression

Share to Epithelium

Share to Mutation

Source

Identifiers

PMID: 8934532

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic loss of 9p21 and mutation of the CDKN2/p16 gene develop as early lesions during neoplastic progression in Barrett's esophagus.PMID 8934532Read ↗

Clonal expansion and loss of heterozygosity at chromosomes 9p and 17p in premalignant esophageal (Barrett's) tissue.Semantic proximity Read ↗

Genetic mechanisms in esophageal carcinogenesis: frequent deletion of 3p and 17p in premalignant lesions.Semantic proximity Read ↗

Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.Semantic proximity Read ↗

17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus.Semantic proximity Read ↗

Evolution of neoplastic cell lineages in Barrett oesophagus.Semantic proximity Read ↗

High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese population.Semantic proximity Read ↗

Characterization of chromosome 9 in human ovarian neoplasia identifies frequent genetic imbalance on 9q and rare alterations involving 9p, including CDKN2.Semantic proximity Read ↗

Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis.Semantic proximity Read ↗

p53 mutations in Barrett's adenocarcinoma and high-grade dysplasia.Semantic proximity Read ↗

Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor.Semantic proximity Read ↗

Immune evasion in HPV − head and neck precancer–cancer transition is driven by an aneuploid switch involving chromosome 9p lossSemantic proximity Read ↗

Frequent allele loss on 9p21-22 defines a smallest common region in the vicinity of the CDKN2 gene in sporadic breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.