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Article

Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions.

Genes, chromosomes & cancer - 1 Feb 1996

Pollock P M, Pearson J V, Hayward N K

Abstract excerpt

The CDKN2 gene, encoding the cyclin-dependent kinase inhibitor p16, is a tumour suppressor gene that maps to chromosome band 9p21-p22. The most common mechanism of inactivation of this gene in human cancers is through homozygous deletion; however, in a smaller proportion of tumours and tumour cell lines intragenic mutations occur. In this study we have compiled a database of over 120 published point mutations in...

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PMID: 8834170
DOI: 10.1002/(SICI)1098-2264(199602)15:2<77::AID-GCC1>3.0.CO;2-0

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