Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions.

doi:10.1002/(SICI)1098-2264(199602)15:2<77::AID-GCC1>3.0.CO;2-0

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Article

Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions.

Genes, chromosomes & cancer - 1 Feb 1996

Pollock P M, Pearson J V, Hayward N K

Abstract excerpt

The CDKN2 gene, encoding the cyclin-dependent kinase inhibitor p16, is a tumour suppressor gene that maps to chromosome band 9p21-p22. The most common mechanism of inactivation of this gene in human cancers is through homozygous deletion; however, in a smaller proportion of tumours and tumour cel...

Topics

Amino Acid Sequence
Carcinoma, Non-Small-Cell Lung
Carrier Proteins
Chromosomes, Human, Pair 9
Codon
Cyclin-Dependent Kinase Inhibitor p16
DNA Mutational Analysis
DNA, Neoplasm
Databases, Factual
Genes, Tumor Suppressor
Genes, p53
Humans
Lung Neoplasms
Melanoma
Molecular Sequence Data
Mutation
Neoplasm Proteins
Neoplasms

Source

Open in PubMed

Identifiers

PMID: 8834170
DOI: 10.1002/(SICI)1098-2264(199602)15:2<77::AID-GCC1>3.0.CO;2-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8834170-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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