Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese population.

Genes, chromosomes & cancer - 1 Mar 2004

Hu Nan, Wang Chaoyu, Su Hua, Li Wen-Jun, Emmert-Buck Michael R, Li Guang, Roth Mark J, Tang Ze-Zhong, Lu Ning, Giffen Carol, Albert Paul S, Taylor Philip R, Goldstein Alisa M

Abstract excerpt

Because previous studies have shown that loss of heterozygosity (LOH) is common on chromosome arm 9p in esophageal squamous cell carcinoma (ESCC) and that genetic alterations in CDKN2A and CDKN2B on 9p are also common, we sought to determine whether LOH and these genetic alterations are related. We performed LOH studies on chromosome bands 9p21-p22 and searched for genetic alterations of CDKN2A and CDKN2B in 56...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA2 Protein
Share to Chromosome Banding

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 9

Share to Cyclin-Dependent Kinase Inhibitor p15

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Esophageal Neoplasms

Share to Genes, p16

Share to Population Surveillance

Source

Identifiers

PMID: 14732922
DOI: 10.1002/gcc.10315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese population.PMID 14732922Read ↗

Genetic variants at 9p21.3 are associated with risk of esophageal squamous cell carcinoma in a Chinese population.Semantic proximity Read ↗

Genome-wide loss of heterozygosity and copy number alteration in esophageal squamous cell carcinoma using the Affymetrix GeneChip Mapping 10 K array.Semantic proximity Read ↗

Aberrant methylation of p16INK4a and deletion of p15INK4b are frequent events in human esophageal cancer in Linxian, China.Semantic proximity Read ↗

Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancersSemantic proximity Read ↗

A genetic variant in CDKN2A/2B locus was associated with poor prognosis in patients with esophageal squamous cell carcinomaSemantic proximity Read ↗

Genomic Characterization of Esophageal Squamous Cell Carcinoma from a High-Risk Population in ChinaSemantic proximity Read ↗

Infrequent p16/CDKN2 alterations in squamous cell carcinoma of the oesophagus.Semantic proximity Read ↗

Frequent germline mutation in the BRCA2 gene in esophageal squamous cell carcinoma patients from a low-risk Chinese population.Semantic proximity Read ↗

Genetic alterations on chromosomes 3 and 9 of esophageal cancer tissues from China.Semantic proximity Read ↗

Frequent allele loss on 9p21-22 defines a smallest common region in the vicinity of the CDKN2 gene in sporadic breast cancer.Semantic proximity Read ↗

Frequent inactivation of the TP53 gene in esophageal squamous cell carcinoma from a high-risk population in China.Semantic proximity Read ↗

Allelic loss of 9p21 and mutation of the CDKN2/p16 gene develop as early lesions during neoplastic progression in Barrett's esophagus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.