Article
In primary human breast carcinomas mutations in exons 5 and 6 of the p53 gene are associated with a high S-phase index.
International journal of cancer - 19 Jun 1993
Merlo G R, Bernardi A, Diella F, Venesio T, Cappa A P, Callahan R, Liscia D S
Abstract excerpt
A series of 121 human breast tumors was screened for point mutations in exons 5 through 8 of the p53 gene, by SSCP analysis. On the same tumor samples, the S-phase index (SPI) was determined by the incorporation of BUdR in fresh tissue. p53 mutations were observed in 29% of the cases. The frequen...
Topics
- Base Sequence
- Breast Neoplasms
- Cell Division
- Chromosomes, Human, Pair 17
- DNA Mutational Analysis
- Exons
- Female
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- S Phase