p53 mutations occur in aggressive breast cancer.

Abstract excerpt

Using a polymerase chain reaction-single strand conformation polymorphism approach we analyzed 96 human primary breast tumors for the presence of mutations in exons 2, 5, 6, 7, 8, and 9 of the p53 gene. These exons have been shown to comprise highly conserved sequences and the portion including exons 5 through 9 is believed to be the target for over 90% of the acquired mutations in human cancer. Eighteen tumors...

Topics

• Breast Neoplasms
• Chromosome Deletion
• Chromosomes, Human, Pair 17
• DNA Mutational Analysis
• Exons
• Female
• Gene Amplification
• Genes, p53
• Humans
• Mutation
• Polymerase Chain Reaction